GRIN2A
Sign in to saveAlso known as EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A, glutamate ionotropic receptor NMDA type subunit 2A
Glutamate Receptor Ionotropic, [NMDA] subunit epsilon-1 is a protein that in humans is encoded by the GRIN2A gene. With 1464 amino acids, the canonical GluN2A subunit isoform is large. GluN2A-short isoforms specific to primates can be produced by alternative splicing and contain 1281 amino acids.
Gene data
GRIN2A- Name
- glutamate ionotropic receptor NMDA type subunit 2A
- Type
- protein-coding
- Position
- 9,753,404–10,183,337 (−)
- Aliases
- EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A
- Ensembl
- ENSG00000183454
- RefSeq RNA
- NM_000833.5, NM_001134407.3, NM_001134408.2, XM_017023172.2, XM_017023173.2
- RefSeq protein
- NP_000824.1, NP_001127879.1, NP_001127880.1, XP_016878661.1, XP_016878662.1
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
glutamate ionotropic receptor NMDA type subunit 2A
- Symbol
- GRIN2A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:9,753,404-10,183,495
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein GRIN2A PDB 2a5s.png
Show 5 more facts
- HomoloGene ID
- 645
- exact match
- identifiers.org/ncbigene/2903
- genomic end
- 10182928
- genomic start
- 9852376
- cytogenetic location
- 16p13.2
via Wikidata · CC0
~2 min read
Article
6 sectionsContents
- Function
- Clinical significance
- Interactions
- See also
- References
- Further reading
Glutamate Receptor Ionotropic, [NMDA] subunit epsilon-1 is a protein that in humans is encoded by the GRIN2A gene. With 1464 amino acids, the canonical GluN2A subunit isoform is large. GluN2A-short isoforms specific to primates can be produced by alternative splicing and contain 1281 amino acids.
== Function ==