GRIN2B

Also known as GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27, glutamate ionotropic receptor NMDA type subunit 2B, NR3

Glutamate Receptor Ionotropic [NMDA] subunit epsilon-2, also known as '''N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B'), is a protein that in humans is encoded by the GRIN2B'' gene.

Gene data

GRIN2B

Name: glutamate ionotropic receptor NMDA type subunit 2B
Type: protein-coding
Aliases: DEE27, EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3

This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017].

via MyGene.info

Gene · Ensembl

glutamate ionotropic receptor NMDA type subunit 2B

Symbol: GRIN2B
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:13,437,942-13,982,138
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein GRIN2B PDB 1S11.png

Show 5 more facts

HomoloGene ID: 646
genomic start: 13437942
exact match: identifiers.org/ncbigene/2904
genomic end: 13982002
cytogenetic location: 12p13.1

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via Wikidata · CC0

~2 min read

Article

7 sections

Contents

NMDA receptors
Function
Ligands
Interactions
See also
References
Further reading

Glutamate Receptor Ionotropic [NMDA] subunit epsilon-2, also known as '''N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B'), is a protein that in humans is encoded by the GRIN2B gene.

== NMDA receptors == N''-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. The NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heterotetramers composed of two molecules of the key receptor subunit NMDAR1 (GRIN1) and two drawn from one or more of the four NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). The NR2 subunit acts as the agonist binding site for glutamate, one of the predominant excitatory neurotransmitter receptors in the mammalian brain.