TBR1

Also known as TBR-1, TES-56, T-box, brain 1, IDDAS, T-box brain transcription factor 1

T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the TBR1 gene. This gene is also known by several other names: T-Brain 1, TBR-1, TES-56, and MGC141978. TBR1 is a member of the TBR1 subfamily of T-box family transcription factors, which share a common DNA-binding domain. Other members of the TBR1 subfamily include EOMES and TBX21. TBR1 is involved in the differentiation and migration of neurons and is required for normal brain development. TBR1 interacts with various genes and proteins in order to regulate cortical development, spec

Gene data

TBR1

Name: T-box brain transcription factor 1
Type: protein-coding
Position: 161,416,297–161,425,870 (+)
Aliases: AUTS5, IDDAS, TBR-1, TES-56
Ensembl: ENSG00000136535
RefSeq RNA: NM_006593.4
RefSeq protein: NP_006584.1

This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015].