T-box
Sign in to saveAlso known as T-Box Domain Proteins, T-Box Domain Protein
T-box refers to a group of transcription factors involved in embryonic limb and heart development. Every T-box protein has a relatively large DNA-binding domain, generally comprising about a third of the entire protein that is both necessary and sufficient for sequence-specific DNA binding. All members of the T-box gene family bind to the "T-box", a DNA consensus sequence of TCACACCT.
Research
6,416 papers- Context-dependent T-BOX transcription factor family: from biology to targeted therapy.Cell communication and signaling : CCS · 2024
- T-Box Genes in Drosophila Mesoderm Development.Current topics in developmental biology · 2017
- The T-box family.Genome biology · 2002
- T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.Immunity · 2015
- Role of T-box genes in cancer, epithelial-mesenchymal transition, and cancer stem cells.Journal of cellular biochemistry · 2022
via PubMed
~3 min read
Article
8 sectionsContents
- Members
- Protein activity
- Defects
- T-box genes
- See also
- References
- Further reading
- External links
T-box refers to a group of transcription factors involved in embryonic limb and heart development. Every T-box protein has a relatively large DNA-binding domain, generally comprising about a third of the entire protein that is both necessary and sufficient for sequence-specific DNA binding. All members of the T-box gene family bind to the "T-box", a DNA consensus sequence of TCACACCT.
==Members== T-boxes are especially important to the development of embryos, found in zebrafish oocyte by Bruce et al 2003 and Xenopus laevis oocyte by Xanthos et al 2001. They are also expressed in later stages, including adult mouse and rabbit studied by Szabo et al 2000.