TBX21
Sign in to saveAlso known as T-PET, T-bet, TBET, TBLYM, T-box 21, T-box transcription factor 21, IMD88
T-box transcription factor TBX21, also called T-bet (T-box expressed in T cells), is a protein that in humans is encoded by the TBX21 gene. Though being for long thought of only as a master regulator of type 1 immune response, T-bet has recently been shown to be implicated in development of various immune cell subsets and maintenance of mucosal homeostasis.
Gene data
TBX21- Name
- T-box transcription factor 21
- Type
- protein-coding
- Position
- 47,733,236–47,746,126 (+)
- Aliases
- IMD88, T-PET, T-bet, TBET, TBLYM
- Ensembl
- ENSG00000073861
- RefSeq RNA
- NM_013351.2
- RefSeq protein
- NP_037483.1
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
T-box transcription factor 21
- Symbol
- TBX21
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:47,733,236-47,746,126
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~8 min read
Encyclopedic overview
9 sectionsContents
- Function
- Role in mucosal homeostasis
- Role in disease
- Atherosclerosis
- Asthma
- Experimental autoimmune encephalomyelitis
- References
- Further reading
- External links
T-box transcription factor TBX21, also called T-bet (T-box expressed in T cells), is a protein that in humans is encoded by the TBX21 gene. Though being for long thought of only as a master regulator of type 1 immune response, T-bet has recently been shown to be implicated in development of various immune cell subsets and maintenance of mucosal homeostasis.
== Function ==
Excerpted from Wikipedia’s “TBX21” article, available under the CC BY-SA 4.0 licence.