GABBR2
Sign in to saveAlso known as GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, gamma-aminobutyric acid type B receptor subunit 2, EIEE59, NDPLHS
Gamma-aminobutyric acid (GABA) B receptor, 2 (GABAB2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.
In the Vinony graph
Within Vinony's link graph, GABBR2 is referenced by 486 other articles, and connects out to PubMed, G protein-coupled recepteishon and Ensembl genome database project.
It is catalogued under topics including Genes on human chromosome 9 and G protein-coupled receptors.
Its subject is documented across 5 Wikipedia language editions.
Gene data
GABBR2- Name
- gamma-aminobutyric acid type B receptor subunit 2
- Type
- protein-coding
- Position
- 98,288,087–98,709,739 (−)
- Aliases
- DEE59, EIEE59, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, NDPLHS
- Ensembl
- ENSG00000136928
- RefSeq RNA
- NM_005458.8, XM_005252316.6, XM_017015331.3, XM_017015332.3, XM_054364210.1
- RefSeq protein
- NP_005449.5, XP_005252373.1, XP_016870820.1, XP_016870821.1, XP_054220185.1
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
gamma-aminobutyric acid type B receptor subunit 2
- Symbol
- GABBR2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:98,288,087-98,709,739
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 55902
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9568
- genomic end
- 98708935
- genomic start
- 98288109
- chromosome
- human chromosome 9
- cytogenetic location
- 9q22.33
- expressed in
- postcentral gyrus
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
Gamma-aminobutyric acid (GABA) B receptor, 2 (GABAB2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.
== Function ==
Excerpted from Wikipedia’s “GABBR2” article, available under the CC BY-SA 4.0 licence.