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GeneQ18028190· pop 6· linked from 312 articles

KCNJ12

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Also known as IRK-2, IRK2, KCNJN1, Kir2.2, Kir2.2v, hIRK, hIRK1, hkir2.2x

ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel that in humans is encoded by the KCNJ12 gene.

Gene data

KCNJ12
Name
potassium inwardly rectifying channel subfamily J member 12
Type
protein-coding
Position
21,376,209–21,419,870 (+)
Aliases
IRK-2, IRK2, KCNJN1, Kir2.2, hIRK, hIRK1, hkir2.2x, kcnj12x
Ensembl
ENSG00000184185
RefSeq RNA
NM_021012.5, XM_005256625.6, XM_011523831.3, XM_054316004.1, XM_054316005.1
RefSeq protein
NP_066292.2, XP_005256682.1, XP_011522133.1, XP_054171979.1, XP_054171980.1

This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

Cholinergic synapse - Homo sapiens (human)Oxytocin signaling pathway - Homo sapiens (human)Neurotransmitter receptors and postsynaptic signal transmissionTransmission across Chemical SynapsesNeuronal SystemActivation of G protein gated Potassium channelsClassical Kir channelsG protein gated Potassium channelsInwardly rectifying K+ channelsPotassium Channels

via MyGene.info

Gene · Ensembl

potassium inwardly rectifying channel subfamily J member 12

Symbol
KCNJ12
Biotype
Protein coding
Organism
Homo sapiens
Location
17:21,376,209-21,419,870
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Image
Chicken Kir22 Crystal Structure.png
Show 8 more facts
HomoloGene ID
7793
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/3768
chromosome
human chromosome 17
genomic start
21376357
genomic end
21419870
cytogenetic location
17p11.2
Commons category
KCNJ12
Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

6 sections
Contents
  • Function
  • Interactions
  • See also
  • References
  • Further reading
  • External links

ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel that in humans is encoded by the KCNJ12 gene.

== Function ==

Excerpted from Wikipedia’s “KCNJ12” article, available under the CC BY-SA 4.0 licence.

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via Wikidata sitelinks · CC0