ANO1
Sign in to saveAlso known as DOG1, ORAOV2, TAOS2, TMEM16A, anoctamin 1
Anoctamin-1 (ANO1), also known as Transmembrane member 16A (TMEM16A), is a protein that, in humans, is encoded by the ANO1 gene. Anoctamin-1 is a voltage-gated calcium-activated anion channel, which acts as a chloride channel and a bicarbonate channel. additionally Anoctamin-1 is apical iodide channel.
Gene data
ANO1- Name
- anoctamin 1
- Type
- protein-coding
- Aliases
- DOG1, INDMS, MYMY7, ORAOV2, TAOS2, TMEM16A
Enables calcium activated cation channel activity; intracellular calcium activated chloride channel activity; and iodide transmembrane transporter activity. Involved in cation transport; inorganic anion transport; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in apical plasma membrane and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
anoctamin 1
- Symbol
- ANO1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:69,985,907-70,189,543
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 75079
- exact match
- identifiers.org/ncbigene/55107
- genomic end
- 70189530
- genomic start
- 69985907
- cytogenetic location
- 11q13.3
Sources (3)
via Wikidata · CC0
~2 min read
Article
6 sectionsContents
- Function
- Structure
- Clinical significance
- References
- Further reading
- External links
Anoctamin-1 (ANO1), also known as Transmembrane member 16A (TMEM16A), is a protein that, in humans, is encoded by the ANO1 gene. Anoctamin-1 is a voltage-gated calcium-activated anion channel, which acts as a chloride channel and a bicarbonate channel. additionally Anoctamin-1 is apical iodide channel.
It is expressed in smooth muscle, epithelial cells, vomeronasal neurons, olfactory sustentacular cells, and is highly expressed in interstitial cells of Cajal (ICC) throughout the gastrointestinal tract.