CD5L

Also known as AIM, API6, PRO229, SP-ALPHA, Spalpha, CT-2, hAIM, CD5 molecule like

CD5 antigen-like is a protein (also known as AIM, for apoptosis inhibitor of macrophage) that in humans is encoded by the CD5L gene. It is expressed by macrophages. It regulates immune responses and inflammation. It plays a crucial role in key intracellular processes like lipid metabolism and apoptosis.

Gene data

CD5L

Name: CD5 molecule like
Type: protein-coding
Position: 157,830,911–157,898,256 (−)
Aliases: AIM, API6, CT-2, PRO229, SP-ALPHA, Spalpha, hAIM
Ensembl: ENSG00000073754
RefSeq RNA: NM_001347698.2, NM_005894.3, XM_017002806.2, XM_054339616.1
RefSeq protein: NP_001334627.1, NP_005885.1, XP_016858295.1, XP_054195591.1

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to act upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

cellular defense response regulation of complement activation

Article

16 sections

Contents

Gene
Structure
Tissue distribution
Functions
Clinical significance
In autoimmune diseases
In cardiopulmonary diseases
Dual role in liver inflammatory damage
Dual role in kidney function
Obesity
Effect of AIM in different diseases
Veterinary medicine
Cat
References
External links
Further reading

==Gene== AIM, also known as apoptosis inhibitor of macrophage, is a 40 kDa protein encoded by the CD5L gene. Its expression is predominantly driven by tissue-resident macrophages via transcriptional activation of nuclear receptors such as LXR and RXR, and/or the transcription factor MAFB. Expression is further regulated by GSK3 through activation of STAT3, which influences CD5L promoter activity.