CD5L
Sign in to saveAlso known as AIM, API6, PRO229, SP-ALPHA, Spalpha, CT-2, hAIM, CD5 molecule like
CD5 antigen-like is a protein (also known as AIM, for apoptosis inhibitor of macrophage) that in humans is encoded by the CD5L gene. It is expressed by macrophages. It regulates immune responses and inflammation. It plays a crucial role in key intracellular processes like lipid metabolism and apoptosis.
Gene data
CD5L- Name
- CD5 molecule like
- Type
- protein-coding
- Position
- 157,830,911–157,898,256 (−)
- Aliases
- AIM, API6, CT-2, PRO229, SP-ALPHA, Spalpha, hAIM
- Ensembl
- ENSG00000073754
- RefSeq RNA
- NM_001347698.2, NM_005894.3, XM_017002806.2, XM_054339616.1
- RefSeq protein
- NP_001334627.1, NP_005885.1, XP_016858295.1, XP_054195591.1
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to act upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Pathways
via MyGene.info
Gene · Ensembl
CD5 molecule like
- Symbol
- CD5L
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:157,827,034-157,898,256
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 55936
- exact match
- identifiers.org/ncbigene/922
- genomic end
- 157868046
- genomic start
- 157830911
- cytogenetic location
- 1q23.1
Sources (3)
via Wikidata · CC0
~12 min read
Article
16 sectionsContents
- Gene
- Structure
- Tissue distribution
- Functions
- Clinical significance
- In autoimmune diseases
- In cardiopulmonary diseases
- Dual role in liver inflammatory damage
- Dual role in kidney function
- Obesity
- Effect of AIM in different diseases
- Veterinary medicine
- Cat
- References
- External links
- Further reading
CD5 antigen-like is a protein (also known as AIM, for apoptosis inhibitor of macrophage) that in humans is encoded by the CD5L gene. It is expressed by macrophages. It regulates immune responses and inflammation. It plays a crucial role in key intracellular processes like lipid metabolism and apoptosis.
==Gene== AIM, also known as apoptosis inhibitor of macrophage, is a 40 kDa protein encoded by the CD5L gene. Its expression is predominantly driven by tissue-resident macrophages via transcriptional activation of nuclear receptors such as LXR and RXR, and/or the transcription factor MAFB. Expression is further regulated by GSK3 through activation of STAT3, which influences CD5L promoter activity.
Available in 9 languages
via Wikidata sitelinks · CC0