CD40LG
Sign in to saveAlso known as CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP
CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and integrin αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells (TFH cells). On TFH cells, CD154 promotes B cell maturation and function by engaging CD40 on the B cell surface and ther
Gene data
CD40LG- Name
- CD40 ligand
- Type
- protein-coding
- Chromosome
- X
- Position
- 136,648,158–136,660,390 (+)
- Aliases
- CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L
- Ensembl
- ENSG00000102245
- RefSeq RNA
- NM_000074.3
- RefSeq protein
- NP_000065.1
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
CD40 ligand
- Symbol
- CD40LG
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:136,648,139-136,660,390
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CD40LG PDB 1aly.png
Show 6 more facts
- HomoloGene ID
- 56
- exact match
- identifiers.org/ncbigene/959
- genomic end
- 135742549
- genomic start
- 136648158
- cytogenetic location
- Xq26.3
- Commons category
- CD154
Sources (7)
via Wikidata · CC0
~5 min read
Article
10 sectionsContents
- History
- Expression
- Specific effects on cells
- Macrophages
- B cells
- Endothelial cells
- Interactions
- References
- Further reading
- External links
CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and integrin αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells (TFH cells). On TFH cells, CD154 promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM syndrome. Absence of CD154 also stops the formation of germinal centers and therefore prohibits antibody affinity maturation, an important process in the adaptive immune system.
== History ==
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