CD47 molecule
Sign in to saveAlso known as CD47, ինտեգրինի հետ կապված ազդանշանային փոխարկիչ, CD47 գլիկոպրոտեին, հակածին մակերեսային որոշիչ սպիտակուց OA3, CD47 հակածին (Rh-կապված հակածին, ինտեգրին-կապված ազդանշանային տվիչ), լեյկոցիտային մակերեսային հակածին CD47, Rh-կապված անտիգեն, ինտեգրինի հետ կապված սպիտակուց
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin 1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a ''don't eat me'' signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis.
Protein · UniProt
Leukocyte surface antigen CD47
- Gene
- CD47
- Organism
- Homo sapiens (Human)
- Length
- 323 aa
- Molecular mass
- 35,214 Da
- Evidence
- 1: Evidence at protein level
Adhesive protein that mediates cell-to-cell interactions (PubMed:11509594, PubMed:15383453). Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:19004835, PubMed:7691831, PubMed:8550562). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:11509594, PubMed:15383453, PubMed:19004835, PubMed:27742621, PubMed:32679764, PubMed:7691831, PubMed:8550562). Plays a role in modulating pulmonary endothelin EDN1 si…
Swiss-Prot (reviewed) · via UniProt
Research
2,248 papers- The development of small-molecule inhibitors targeting CD47.Drug discovery today · 2021
- The CD47-SIRPα Immune Checkpoint.Immunity · 2020
- CD47 peptide-cloaked lipid nanoparticles promote cell-specific mRNA delivery.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
- Human Single-Nucleus RNA Sequencing Identifies CD47 as a Therapeutic Target for Doxorubicin-Induced Cardiomyopathy.Circulation · 2025
- Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect.Nature cancer · 2022
via PubMed
~11 min read
Encyclopedic overview
20 sectionsContents
- Structure
- Interactions
- Thrombospondin (TSP)
- Signal-regulatory protein (SIRP)
- Integrins
- Function
- Tumor cells
- Cell proliferation
- Cell death
- Migration
- Stromal cells
- Angiogenesis
- Inflammatory response
- Insulin secretion
- Clinical significance
- As a potential drug target
- See also
- References
- Further reading
- External links
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin 1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a ''don't eat me'' signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis.
CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a role in insulin secretion, as well as immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Expression in equine cutaneous tumors has been reported as well.
Excerpted from Wikipedia’s “CD47 molecule” article, available under the CC BY-SA 4.0 licence.