DLGAP4

Also known as DAP-4, DAP4, DLP4, SAPAP-4, SAPAP4, discs large homolog associated protein 4, DLG associated protein 4

Disks large-associated protein 4 (DAP-4) also known as SAP90/PSD-95-associated protein 4 (SAPAP-4) is a protein that in humans is encoded by the DLGAP4 gene.

Gene data

DLGAP4

Name: DLG associated protein 4
Type: protein-coding
Position: 36,306,302–36,528,637 (+)
Aliases: DAP-4, DAP4, DLP4, SAPAP-4, SAPAP4
Ensembl: ENSG00000080845
RefSeq RNA: NM_001042486.4, NM_001365621.2, NM_001388257.1, NM_001388260.1, NM_001388262.1
RefSeq protein: NP_001035951.1, NP_001352550.1, NP_001375186.1, NP_001375189.1, NP_001375191.1

The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

signaling modulation of chemical synaptic transmission regulation of synapse maturation modification of postsynaptic structure

Molecular function

protein binding molecular adaptor activity

Cellular component

plasma membrane membrane neuromuscular junction synapse glutamatergic synapse glutamatergic synapse cholinergic synapse postsynaptic specialization

Pathways

Neuronal System Neuronal System Neurexins and neuroligins Neurexins and neuroligins Protein-protein interactions at synapses Protein-protein interactions at synapses

via MyGene.info

Gene · Ensembl

DLG associated protein 4

Symbol: DLGAP4
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:36,306,302-36,528,637
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 8935
exact match: identifiers.org/ncbigene/22839
genomic start: 34894258
genomic end: 35157040
cytogenetic location: 20q11.23

Sources (3)

via Wikidata · CC0

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Contents

Function
References
Further reading

Disks large-associated protein 4 (DAP-4) also known as SAP90/PSD-95-associated protein 4 (SAPAP-4) is a protein that in humans is encoded by the DLGAP4 gene.

== Function ==