HLA-DRB5

Also known as HLA-DRB, major histocompatibility complex, class II, DR beta 5, HLA-DRB5*

HLA class II histocompatibility antigen, DRB5 beta chain is a protein that in humans is encoded by the HLA-DRB5 gene.

Gene data

HLA-DRB5

Name: major histocompatibility complex, class II, DR beta 5
Type: protein-coding
Position: 32,516,622–32,530,369 (−)
Aliases: DRB5, HLA-DRB5*
Ensembl: ENSG00000198502
RefSeq RNA: NM_002125.4, XM_011514562.3
RefSeq protein: NP_002116.2, XP_011512864.1

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020].

Gene Ontology

Biological process

peptide antigen assembly with MHC class II protein complex immune response antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of immune response positive regulation of T cell activation

Molecular function

protein binding MHC class II protein complex binding peptide antigen binding peptide antigen binding

Cellular component

Golgi membrane lysosomal membrane lysosomal membrane lysosomal membrane lysosomal membrane endoplasmic reticulum membrane Golgi apparatus plasma membrane

Pathways

Phagosome - Homo sapiens (human)Cell adhesion molecules - Homo sapiens (human)Antigen processing and presentation - Homo sapiens (human)Hematopoietic cell lineage - Homo sapiens (human)Th1 and Th2 cell differentiation - Homo sapiens (human)Th17 cell differentiation - Homo sapiens (human)Intestinal immune network for IgA production - Homo sapiens (human)Type I diabetes mellitus - Homo sapiens (human)Leishmaniasis - Homo sapiens (human)Toxoplasmosis - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

major histocompatibility complex, class II, DR beta 5

Symbol: HLA-DRB5
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:32,516,622-32,530,369
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~2 min read

Encyclopedic overview

6 sections

Contents

Function
Gene structure and polymorphisms
Gene expression
See also
References
Further reading

HLA class II histocompatibility antigen, DRB5 beta chain is a protein that in humans is encoded by the HLA-DRB5 gene.

== Function == The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages).

Excerpted from Wikipedia’s “HLA-DRB5” article, available under the CC BY-SA 4.0 licence.