BUB3

Also known as BUB3L, hBUB3, BUB3, mitotic checkpoint protein, BUB3 mitotic checkpoint protein

Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene.

Gene data

BUB3

Name: BUB3 mitotic checkpoint protein
Type: protein-coding
Position: 123,154,395–123,170,467 (+)
Aliases: BUB3L, hBUB3
Ensembl: ENSG00000154473
RefSeq RNA: NM_001007793.3, NM_004725.4
RefSeq protein: NP_001007794.1, NP_004716.1

This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

mitotic spindle assembly checkpoint signaling mitotic spindle assembly checkpoint signaling attachment of spindle microtubules to kinetochore protein localization to kinetochore

Molecular function

protein binding ubiquitin binding

Cellular component

kinetochore kinetochore kinetochore nucleus nucleoplasm nucleoplasm cytosol mitotic checkpoint complex

Pathways

Cell cycle - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Amplification of signal from the kinetochores Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Signal Transduction Cell Cycle APC/C-mediated degradation of cell cycle proteins Cdc20:Phospho-APC/C mediated degradation of Cyclin A

via MyGene.info

Gene · Ensembl

BUB3 mitotic checkpoint protein

Symbol: BUB3
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:123,154,365-123,313,144
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: BUB3 protein.jpg

Show 5 more facts

exact match: identifiers.org/ncbigene/9184
HomoloGene ID: 3470
genomic start: 123154402
cytogenetic location: 10q26.13
genomic end: 124924886

Sources (4)

via Wikidata · CC0

~6 min read

Article

9 sections

Contents

Function
Role in the spindle assembly checkpoint
Structure
Interactions
Regulation
Clinical significance
References
Further reading
External links

Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene.

Bub3 is a protein involved with the regulation of the Spindle Assembly Checkpoint (SAC); though BUB3 is non-essential in yeast, it is essential in higher eukaryotes. As one of the checkpoint proteins, Bub3 delays the irreversible onset of anaphase through direction of kinetochore localization during prometaphase to achieve biorientation. In directing the kinetochore-microtubule interaction, this ensures the proper (and consequently, bioriented) attachment of the chromosomes prior to anaphase. Bub3 and its related proteins that form the Spindle Assembly Checkpoint (SAC) inhibit the action of the Anaphase Promoting Complex (APC), preventing early anaphase entry and mitotic exit; this serves as a mechanism for the fidelity of chromosomal segregation.