BUB3

Also known as BUB3L, hBUB3, BUB3, mitotic checkpoint protein, BUB3 mitotic checkpoint protein

Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene.

Gene data

BUB3

Name: BUB3 mitotic checkpoint protein
Type: protein-coding
Position: 123,154,395–123,170,467 (+)
Aliases: BUB3L, hBUB3
Ensembl: ENSG00000154473
RefSeq RNA: NM_001007793.3, NM_004725.4
RefSeq protein: NP_001007794.1, NP_004716.1

This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

mitotic spindle assembly checkpoint signaling mitotic spindle assembly checkpoint signaling attachment of spindle microtubules to kinetochore

Article

9 sections

Contents

Function
Role in the spindle assembly checkpoint
Structure
Interactions
Regulation
Clinical significance
References
Further reading
External links

Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene.

Bub3 is a protein involved with the regulation of the Spindle Assembly Checkpoint (SAC); though BUB3 is non-essential in yeast, it is essential in higher eukaryotes. As one of the checkpoint proteins, Bub3 delays the irreversible onset of anaphase through direction of kinetochore localization during prometaphase to achieve biorientation. In directing the kinetochore-microtubule interaction, this ensures the proper (and consequently, bioriented) attachment of the chromosomes prior to anaphase. Bub3 and its related proteins that form the Spindle Assembly Checkpoint (SAC) inhibit the action of the Anaphase Promoting Complex (APC), preventing early anaphase entry and mitotic exit; this serves as a mechanism for the fidelity of chromosomal segregation.