BUB3
Sign in to saveAlso known as BUB3L, hBUB3, BUB3, mitotic checkpoint protein, BUB3 mitotic checkpoint protein
gene umano
Gene data
BUB3- Name
- BUB3 mitotic checkpoint protein
- Type
- protein-coding
- Position
- 123,154,365–123,313,144 (+)
- Aliases
- BUB3L, hBUB3
- Ensembl
- ENSG00000154473
- RefSeq RNA
- NM_001007793.3, NM_004725.4
- RefSeq protein
- NP_001007794.1, NP_004716.1
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
Cell cycle - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint componentsAmplification of signal from the kinetochoresInactivation of APC/C via direct inhibition of the APC/C complexAmplification of signal from unattached kinetochores via a MAD2 inhibitory signalSignal TransductionCell CycleAPC/C-mediated degradation of cell cycle proteinsCdc20:Phospho-APC/C mediated degradation of Cyclin A
via MyGene.info
Gene · Ensembl
BUB3 mitotic checkpoint protein
- Symbol
- BUB3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:123,154,365-123,313,144
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- BUB3 protein.jpg
Show 8 more facts
- exact match
- identifiers.org/ncbigene/9184
- HomoloGene ID
- 3470
- found in taxon
- Homo sapiens
- genomic start
- 123154402
- cytogenetic location
- 10q26.13
- genomic end
- 124924886
- chromosome
- human chromosome 10
- expressed in
- gonad
Sources (4)
via Wikidata · CC0