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GeneQ18033895· pop 6· linked from 5 articles

ZW10

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Also known as HZW10, KNTC1AP, zw10 kinetochore protein

Centromere/kinetochore protein zw10 homolog is a protein that in humans is encoded by the ZW10 gene. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.

Gene data

ZW10

Name: zw10 kinetochore protein
Type: protein-coding
Position: 113,733,183–113,773,746 (−)
Aliases: HZW10, KNTC1AP
Ensembl: ENSG00000086827
RefSeq RNA: NM_004724.4, XM_017018558.3, XM_054370507.1
RefSeq protein: NP_004715.1, XP_016874047.1, XP_054226482.1

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011].

Gene Ontology

Biological process

mitotic sister chromatid segregation establishment of mitotic spindle orientation mitotic cell cycle endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Golgi organization Golgi organization

Molecular function

protein binding centromeric DNA binding

Cellular component

chromosome, centromeric region kinetochore spindle pole nucleus nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane

Pathways

Amplification of signal from the kinetochores Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Signal Transduction Cell Cycle Signaling by Rho GTPases RHO GTPase Effectors Membrane Trafficking Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase

via MyGene.info

Gene · Ensembl

zw10 kinetochore protein

Symbol: ZW10
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:113,729,794-113,773,771
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 37959
exact match: identifiers.org/ncbigene/9183
genomic end: 113773735
genomic start: 113603909
cytogenetic location: 11q23.2

Sources (4)

via Wikidata · CC0

~2 min read

Article

4 sections

Contents

Function
Interactions
References
Further reading

Centromere/kinetochore protein zw10 homolog is a protein that in humans is encoded by the ZW10 gene. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.

==Function==

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Categories

Genes on human chromosome 11 Protein pages needing a picture