CCNH

Also known as CAK, CycH, p34, p37, Cyclin H

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 9 inbound references to CCNH, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under the topic Genes on human chromosome 5.

Vinony links it to 5 Wikipedia language editions.

Gene data

CCNH

Name: cyclin H
Type: protein-coding
Position: 87,311,473–87,413,029 (−)
Aliases: CAK, CycH, p34, p37
Ensembl: ENSG00000134480
RefSeq RNA: NM_001199189.2, NM_001239.4, NM_001363539.2, NM_001364075.2, NM_001364076.2
RefSeq protein: NP_001186118.1, NP_001230.1, NP_001350468.1, NP_001351004.1, NP_001351005.1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010].