SEMA3A
Sign in to saveAlso known as COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL
Semaphorin-3A is a protein that in humans is encoded by the SEMA3A gene.
Gene data
SEMA3A- Name
- semaphorin 3A
- Type
- protein-coding
- Aliases
- COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
semaphorin 3A
- Symbol
- SEMA3A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:83,902,491-84,492,939
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein SEMA3A PDB 1q47.png
Show 5 more facts
- HomoloGene ID
- 31358
- genomic end
- 84122040
- exact match
- identifiers.org/ncbigene/10371
- genomic start
- 83585093
- cytogenetic location
- 7q21.11
via Wikidata · CC0
~3 min read
Article
5 sectionsContents
- Function
- Clinical significance
- References
- Further reading
- External links
Semaphorin-3A is a protein that in humans is encoded by the SEMA3A gene.
== Function ==