Plexin
Sign in to saveA plexin is a protein which acts as a receptor for semaphorin family signaling proteins. It is classically known for its expression on the surface of axon growth cones and involvement in signal transduction to steer axon growth away from the source of semaphorin. Plexin also has implications in development of other body systems by activating GTPase enzymes to induce a number of intracellular biochemical changes leading to a variety of downstream effects.
Clinical Trials
4 registered- PHASE1COMPLETEDPlexin B2 Gene Expression and Polymorphisms in PsoriasisSouth Valley University · NCT05184348
- PHASE2RECRUITINGIVIG in the Treatment of Autoimmune Small Fiber Neuropathy With TS-HDS, FGFR-3, or Plexin D1 AntibodiesEndeavor Health · NCT04153422
- UNKNOWNPlexin D1 as a Potential Biomarker inPM/DMAssiut University · NCT05637931
- PHASE1TERMINATEDSAD and MAD Study of FTX-101 in Healthy Male SubjectsFind Therapeutics · NCT06617546
~5 min read
Article
11 sectionsContents
- Structure
- Extracellular
- Intracellular
- Classes
- Function
- Axon guidance
- Angiogenesis and heart development
- Skeletal and kidney development
- Immune system
- Role in intelligence
- References
A plexin is a protein which acts as a receptor for semaphorin family signaling proteins. It is classically known for its expression on the surface of axon growth cones and involvement in signal transduction to steer axon growth away from the source of semaphorin. Plexin also has implications in development of other body systems by activating GTPase enzymes to induce a number of intracellular biochemical changes leading to a variety of downstream effects.
== Structure ==