SEMA4G
Sign in to saveAlso known as semaphorin 4G
Semaphorin-4G is a protein in humans encoded by the SEMA4G gene.
Gene data
SEMA4G- Name
- semaphorin 4G
- Type
- protein-coding
- Position
- 100,969,493–100,985,871 (+)
- Ensembl
- ENSG00000095539
- RefSeq RNA
- NM_001203244.1, NM_001393925.1, NM_017893.4, NR_172052.1, NR_172053.1
- RefSeq protein
- NP_001190173.1, NP_001380854.1, NP_060363.2
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
semaphorin 4G
- Symbol
- SEMA4G
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:100,969,493-100,985,871
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Semaphorin-4G is a protein in humans encoded by the SEMA4G gene.
Semaphorins are a large family of conserved, secreted and membrane associated proteins which possess a semaphoring (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Semaphorins maintain cell motility and attachment in axon guidance, immune cell maintenance, vascular growth and tumour movement.
Excerpted from Wikipedia’s “SEMA4G” article, available under the CC BY-SA 4.0 licence.