EIF4G2

Also known as AAG1, DAP5, NAT1, P97, eukaryotic translation initiation factor 4 gamma 2

Eukaryotic translation initiation factor 4 gamma 2 (also called p97, NAT1, and DAP-5) is a protein that in humans is encoded by the EIF4G2 gene.

In the Vinony graph

Within Vinony's link graph, EIF4G2 is referenced by 211 other articles, and connects out to PubMed, translation and human chromosome 11.

It is catalogued under the topic Genes on human chromosome 11.

Its subject is documented across 5 Wikipedia language editions.

Gene data

EIF4G2

Name: eukaryotic translation initiation factor 4 gamma 2
Type: protein-coding
Position: 10,796,817–10,808,947 (−)
Aliases: AAG1, DAP5, NAT1, P97
Ensembl: ENSG00000110321
RefSeq RNA: NM_001042559.3, NM_001172705.1, NM_001418.4
RefSeq protein: NP_001036024.3, NP_001166176.1, NP_001409.3

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008].