STAT4

Also known as SLEB11, signal transducer and activator of transcription 4

Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. STAT proteins are key activators of gene transcription which bind to DNA in response to cytokine gradient. STAT proteins are a common part of Janus kinase (JAK)- signalling pathways, activated by cytokines.STAT4 is required for the development of Th1 cells from naive CD4+ T cells and IFN-γ production in response to IL-12. There are two known STAT4 transcripts, STAT4α and STAT4β, differing in the levels of inter

Gene data

STAT4

Name: signal transducer and activator of transcription 4
Type: protein-coding
Position: 191,029,570–191,178,435 (−)
Aliases: DPMC, SLEB11
Ensembl: ENSG00000138378
RefSeq RNA: NM_001243835.2, NM_003151.4, XM_006712719.4, XM_047445603.1, XM_047445604.1
RefSeq protein: NP_001230764.1, NP_003142.1, XP_006712782.1, XP_047301559.1, XP_047301560.1

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011].