STAT4

Also known as SLEB11, signal transducer and activator of transcription 4

gene da espécie Homo sapiens

In the Vinony graph

Within Vinony's link graph, STAT4 is referenced by 848 other articles, and connects out to interferon gamma, PubMed and homeobox.

Vinony files it under Gene expression, Genes on human chromosome 2 and Immune system.

Its subject is documented across 9 Wikipedia language editions.

Gene data

STAT4

Name: signal transducer and activator of transcription 4
Type: protein-coding
Position: 191,029,570–191,178,435 (−)
Aliases: DPMC, SLEB11
Ensembl: ENSG00000138378
RefSeq RNA: NM_001243835.2, NM_003151.4, XM_006712719.4, XM_047445603.1, XM_047445604.1
RefSeq protein: NP_001230764.1, NP_003142.1, XP_006712782.1, XP_047301559.1, XP_047301560.1

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011].