SMAD3
Sign in to saveAlso known as HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3
Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.
Gene data
SMAD3- Name
- SMAD family member 3
- Type
- protein-coding
- Position
- 67,063,763–67,195,173 (+)
- Aliases
- HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, hMAD-3, hSMAD3, mad3
- Ensembl
- ENSG00000166949
- RefSeq RNA
- NM_001145102.2, NM_001145103.2, NM_001145104.2, NM_001407011.1, NM_001407012.1
- RefSeq protein
- NP_001138574.1, NP_001138575.1, NP_001138576.1, NP_001393940.1, NP_001393941.1
The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, May 2022].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SMAD family member 3
- Symbol
- SMAD3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:67,063,763-67,195,173
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~13 min read
Encyclopedic overview
19 sectionsContents
- Gene
- Protein
- Structure
- MH1 domain
- MH2 domain
- Functions and interactions
- TGF-β/SMAD signaling pathway
- TGF-β/SMAD3-induced repression
- Clinical significance
- Diseases
- Role in cancer
- Prostate
- Colorectal
- Breast
- Kidney
- Nomenclature
- References
- Further reading
- External links
Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.
SMAD3 is a member of the SMAD family of proteins. It acts as a mediator of the signals initiated by the transforming growth factor beta (TGF-β) superfamily of cytokines, which regulate cell proliferation, differentiation and death. Based on its essential role in TGF beta signaling pathway, SMAD3 has been related with tumor growth in cancer development.
Excerpted from Wikipedia’s “SMAD3” article, available under the CC BY-SA 4.0 licence.