PRUNE2

Also known as A214N16.3, BMCC1, BNIPXL, C9orf65, KIAA0367, bA214N16.3, prune homolog 2 (Drosophila), prune homolog 2

Protein prune homolog 2 is a protein that in humans is encoded by the PRUNE2 gene.

In the Vinony graph

Vinony's link graph records 2 inbound references to PRUNE2, and connects out to PubMed, human chromosome 9 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 9.

Vinony links it to 6 Wikipedia language editions.

Gene data

PRUNE2

Name: prune homolog 2 with BCH domain
Type: protein-coding
Position: 76,611,376–76,906,591 (−)
Aliases: BMCC1, BNIPXL, C9orf65, KIAA0367
Ensembl: ENSG00000106772
RefSeq RNA: NM_001308047.2, NM_001308048.2, NM_001308049.2, NM_001308050.2, NM_001308051.2
RefSeq protein: NP_001294976.1, NP_001294977.1, NP_001294978.1, NP_001294979.1, NP_001294980.1

The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].