DNAJA2

Also known as CPR3, DJ3, DJA2, DNAJ, DNJ3, HIRIP4, PRO3015, RDJ2

DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene.

In the Vinony graph

Vinony's link graph records 108 inbound references to DNAJA2, and connects out to PubMed, human chromosome 16 and Ensembl genome database project.

It is catalogued under topics including Genes on human chromosome 16 and Heat shock proteins.

Vinony links it to 6 Wikipedia language editions.

Gene data

DNAJA2

Name: DnaJ heat shock protein family (Hsp40) member A2
Type: protein-coding
Position: 46,955,362–46,973,709 (−)
Aliases: CPR3, DJ3, DJA2, DNAJ, DNJ3, HIRIP4, PRO3015, RDJ2
Ensembl: ENSG00000069345
RefSeq RNA: NM_005880.4
RefSeq protein: NP_005871.1

The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

protein folding positive regulation of cell population proliferation response to heat cellular response to heat protein refolding protein refolding

Molecular function

ATPase activator activity ATPase activator activity ATPase activator activity protein binding ATP binding Hsp70 protein binding heat shock protein binding protein-folding chaperone binding

Cellular component

cytosol cytosol cytosol membrane extracellular exosome

Pathways

Protein processing in endoplasmic reticulum - Homo sapiens (human)Disease Cellular responses to stress HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Infectious disease Cellular responses to stimuli Viral Infection Pathways Dengue Virus Infection Dengue Virus Genome Translation and Replication

via MyGene.info

Gene · Ensembl

DnaJ heat shock protein family (Hsp40) member A2

Symbol: DNAJA2
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:46,955,362-46,973,709
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 21193
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10294
genomic end: 46973674
genomic start: 46989299
chromosome: human chromosome 16
cytogenetic location: 16q11.2
expressed in: prefrontal cortex

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

3 sections

Contents

References
Further reading
External links

DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene.

The protein encoded by this gene shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of this protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding interacting proteins, HIRIPs, have been identified. HIRIP4 was isolated by virtue of its interaction with this protein; however, its exact function is not known. The sequence of HIRIP4 protein is highly homologous to the human DNJ3/CPR3, mouse Dj3 and rat Dj2 gene products.

Excerpted from Wikipedia’s “DNAJA2” article, available under the CC BY-SA 4.0 licence.