SLIT2

Name

slit guidance ligand 2

Type

protein-coding

Aliases

SLIL3, Slit-2

This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

via MyGene.info

Gene · Ensembl

slit guidance ligand 2

Symbol

SLIT2

Biotype

Protein coding

Organism

Homo sapiens

Location

4:20,251,897-20,621,249

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein SLIT2 PDB 2V70.png

via Wikidata · CC0