SLIT2

Also known as SLIL3, Slit-2, slit guidance ligand 2

Slit homolog 2 protein is a protein that in humans is encoded by the SLIT2 gene.

In the Vinony graph

Within Vinony's link graph, SLIT2 is referenced by 8 other articles, and connects out to PubMed, human chromosome 4 and Ensembl genome database project.

It is catalogued under topics including Genes on human chromosome 4 and Slit proteins.

Its subject is documented across 7 Wikipedia language editions.

Gene data

SLIT2

Name: slit guidance ligand 2
Type: protein-coding
Position: 20,251,897–20,621,249 (+)
Aliases: SLIL3, Slit-2
Ensembl: ENSG00000145147
RefSeq RNA: NM_001289135.3, NM_001289136.3, NM_004787.4, XM_005248211.3, XM_006713986.3
RefSeq protein: NP_001276064.1, NP_001276065.1, NP_004778.1, XP_005248268.1, XP_006714049.1

This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].