HOMER3

Also known as HOMER-3, VESL3, homer scaffolding protein 3, homer scaffold protein 3

Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.

Gene data

HOMER3

Name: homer scaffold protein 3
Type: protein-coding
Position: 18,929,201–18,941,728 (−)
Aliases: HOMER-3, VESL3
Ensembl: ENSG00000051128
RefSeq RNA: NM_001145721.1, NM_001145722.2, NM_001145724.1, NM_004838.4, NR_027297.1
RefSeq protein: NP_001139193.1, NP_001139194.1, NP_001139196.1, NP_004829.3, XP_047295689.1

This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009].