SUN2

Also known as UNC84B, Sad1 and UNC84 domain containing 2

Protein unc-84 homolog B is a protein that in humans is encoded by the UNC84B gene.

In the Vinony graph

Vinony's link graph records 2 inbound references to SUN2, and connects out to PubMed, human chromosome 22 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 22.

Vinony links it to 6 Wikipedia language editions.

Gene data

SUN2

Name: Sad1 and UNC84 domain containing 2
Type: protein-coding
Position: 38,733,280–38,794,198 (−)
Aliases: UNC84B, rab5IP
Ensembl: ENSG00000100242
RefSeq RNA: NM_001199579.2, NM_001199580.2, NM_001394427.1, NM_001394428.1, NM_001394429.1
RefSeq protein: NP_001186508.1, NP_001186509.1, NP_001381356.1, NP_001381357.1, NP_001381358.1

SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010].