SUN2
Sign in to saveAlso known as UNC84B, Sad1 and UNC84 domain containing 2
Protein unc-84 homolog B is a protein that in humans is encoded by the UNC84B gene.
Gene data
SUN2- Name
- Sad1 and UNC84 domain containing 2
- Type
- protein-coding
- Position
- 38,733,280–38,794,143 (−)
- Aliases
- UNC84B, rab5IP
- Ensembl
- ENSG00000100242
- RefSeq RNA
- NM_001199579.2, NM_001199580.2, NM_001394427.1, NM_001394428.1, NM_001394429.1
- RefSeq protein
- NP_001186508.1, NP_001186509.1, NP_001381356.1, NP_001381357.1, NP_001381358.1
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
Sad1 and UNC84 domain containing 2
- Symbol
- SUN2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:38,733,280-38,794,198
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 9113
- exact match
- identifiers.org/ncbigene/25777
- genomic start
- 39130730
- genomic end
- 39190148
- cytogenetic location
- 22q13.1
Sources (3)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Protein unc-84 homolog B is a protein that in humans is encoded by the UNC84B gene.
==References==