DPYSL2
Sign in to saveAlso known as CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2
Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene.
In the Vinony graph
Within Vinony's link graph, DPYSL2 is referenced by 6 other articles, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 8.
Its subject is documented across 5 Wikipedia language editions.
Gene data
DPYSL2- Name
- dihydropyrimidinase like 2
- Type
- protein-coding
- Position
- 26,514,031–26,658,178 (+)
- Aliases
- CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2
- Ensembl
- ENSG00000092964
- RefSeq RNA
- NM_001197293.3, NM_001244604.2, NM_001386.6
- RefSeq protein
- NP_001184222.1, NP_001231533.1, NP_001377.1
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
dihydropyrimidinase like 2
- Symbol
- DPYSL2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:26,514,031-26,658,178
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein DPYSL2 PDB 2gse.png
Show 7 more facts
- HomoloGene ID
- 74392
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1808
- genomic end
- 26515694
- genomic start
- 26514031
- chromosome
- human chromosome 8
- cytogenetic location
- 8p21.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene.
==Interactions== DPYSL2 has been shown to interact with CRMP1, Adaptor-related protein complex 2, alpha 1 and NUMB.
Excerpted from Wikipedia’s “DPYSL2” article, available under the CC BY-SA 4.0 licence.