CASP8AP2

Name

caspase 8 associated protein 2

Type

protein-coding

Position

89,829,894–89,874,436 (+)

Aliases

CED-4, FLASH, RIP25

Ensembl

ENSG00000288475

RefSeq RNA

NM_001137667.2, NM_001137668.2, NM_012115.4, XM_054332061.1, XM_054332062.1

RefSeq protein

NP_001131139.1, NP_001131140.1, NP_036247.1, XP_054188036.1, XP_054188037.1

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008].