CD2AP
Sign in to saveAlso known as CMS, CD2-associated protein, CD2 associated protein
CD2-associated protein is a protein that in humans is encoded by the CD2AP gene.
Gene data
CD2AP- Name
- CD2 associated protein
- Type
- protein-coding
- Aliases
- CMS
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
CD2 associated protein
- Symbol
- CD2AP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:47,477,732-47,627,275
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CD2AP PDB 2j6f.png
Show 5 more facts
- HomoloGene ID
- 7663
- exact match
- identifiers.org/ncbigene/23607
- genomic end
- 47594999
- genomic start
- 47445525
- cytogenetic location
- 6p12.3
via Wikidata · CC0
~1 min read
Article
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
CD2-associated protein is a protein that in humans is encoded by the CD2AP gene.
== Function ==