CD200

Also known as CD200 molecule, MOX1, MOX2, MRC, OX-2, CD-200

OX-2 membrane glycoprotein, also named CD200 (Cluster of Differentiation 200) is a human protein encoded by the gene. In humans, the CD200 gene is located on chromosome 3 in proximity to genes encoding the other B7 proteins CD80/CD86. In mice, the CD200 gene is located on chromosome 16.

Gene data

CD200

Name: CD200 molecule
Type: protein-coding
Aliases: MOX1, MOX2, MRC, OX-2

This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].

via MyGene.info

Gene · Ensembl

CD200 molecule

Symbol: CD200
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:112,332,235-112,363,181
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: CD200.png

Show 5 more facts

HomoloGene ID: 4344
exact match: identifiers.org/ncbigene/4345
genomic end: 112081659
genomic start: 112051194
cytogenetic location: 3q13.2

Sources (4)

via Wikidata · CC0

~7 min read

Article

14 sections

Contents

Expression
Soluble form
Truncated form
Function
Mechanism of action
Clinical significance
Pathogens modulate CD200-CD200R axis
In cancer
In transplantation
As a drug target
See also
References
Further reading
External links

The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two IgSF immunoglobulin domains, transmembrane region and a 19 amino acid long cytoplasmatic domain. CD 200 belongs to the immunoglobulin superfamily, particularly belongs to the B7 receptor family.