CD109

Also known as CPAMD7, p180, r150, CD109 molecule

CD109 (Cluster of Differentiation 109) is a human gene.

In the Vinony graph

Within Vinony's link graph, CD109 is referenced by 359 other articles, and connects out to PubMed, Ensembl genome database project and CD1.

Vinony files it under Clusters of differentiation and Genes on human chromosome 6.

Its subject is documented across 5 Wikipedia language editions.

Gene data

CD109

Name: CD109 molecule
Type: protein-coding
Position: 73,695,779–73,828,316 (+)
Aliases: CPAMD7, HPA-15, p180, r150
Ensembl: ENSG00000156535
RefSeq RNA: NM_001159587.3, NM_001159588.3, NM_133493.5, XM_047418211.1, XM_047418212.1
RefSeq protein: NP_001153059.1, NP_001153060.1, NP_598000.2, XP_047274167.1, XP_047274168.1

This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014].

Gene Ontology

Biological process

negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of wound healing

Molecular function

endopeptidase inhibitor activity

Cellular component

extracellular region extracellular region plasma membrane plasma membrane plasma membrane cell surface platelet alpha granule membrane

Pathways

Hemostasis Platelet degranulation Post-translational modification: synthesis of GPI-anchored proteins Metabolism of proteins Post-translational protein modification Platelet activation, signaling and aggregation Response to elevated platelet cytosolic Ca2+

via MyGene.info

Gene · Ensembl

CD109 molecule

Symbol: CD109
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:73,695,779-73,828,316
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 25183
genomic start: 74405508
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/135228
genomic end: 74538040
chromosome: human chromosome 6
cytogenetic location: 6q13
expressed in: gums

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

4 sections

Contents

See also
References
Further reading
External links

CD109 (Cluster of Differentiation 109) is a human gene.

CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system (HPA15), implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin et al., 2002).[supplied by OMIM]

Excerpted from Wikipedia’s “CD109” article, available under the CC BY-SA 4.0 licence.