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CD7 molecule
Sign in to saveAlso known as p41 protein, T-cell surface antigen Leu-9, CD7, T-cell antigen CD7, TP41, GP40, T-cell leukemia antigen, CD7 antigen (p41)
CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.
Protein · UniProt
T-cell antigen CD7
- Gene
- CD7
- Organism
- Homo sapiens (Human)
- Length
- 240 aa
- Molecular mass
- 25,409 Da
- Evidence
- 1: Evidence at protein level
Transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors (PubMed:7506726). Plays a costimulatory role in T-cell activation upon binding to its ligand K12/SECTM1 (PubMed:10652336). In turn, mediates the production of cytokines such as IL-2 (PubMed:1709867). On resting NK-cells, CD7 activation results in a significant induction of interferon-gamma levels (PubMed:7506726)
Swiss-Prot (reviewed) · via UniProt
Research
299 papers- Structure and function of the CD7 molecule.Critical reviews in immunology · 1999
- Autologous Nanobody-Derived Fratricide-Resistant CD7-CAR T-cell Therapy for Patients with Relapsed and Refractory T-cell Acute Lymphoblastic Leukemia/Lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
- Naturally selected CD7 CAR-T therapy without genetic manipulations for T-ALL/LBL: first-in-human phase 1 clinical trial.Blood · 2022
- CAR-T cell therapy in AML: recent progress and future perspectives.International journal of hematology · 2024
- Chimeric antigen receptor T-cell therapy for T-cell acute lymphoblastic leukemia.Haematologica · 2024
via PubMed
~1 min read
Article
7 sectionsContents
- Function
- See also
- Interactions
- Clinical significance
- References
- Further reading
- External links
CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.
== Function == This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.