CD93 molecule
Sign in to saveAlso known as C1qR, C1q receptor 1, C1qRp, C1q/MBL/SPA receptor, complement component C1q receptor, complement component 1 q subcomponent receptor 1, matrix-remodelling associated 4, matrix-remodeling-associated protein 4
CD93 (Cluster of Differentiation 93) is a protein that in humans is encoded by the CD93 gene. CD93 is a C-type lectin transmembrane receptor which plays a role not only in cell–cell adhesion processes but also in host defense.
In the Vinony graph
Within Vinony's link graph, CD93 molecule is referenced by 361 other articles, and connects out to PubMed, Ensembl genome database project and CD1.
It sits within the topics Clusters of differentiation and Genes on human chromosome 20.
Its subject is documented across 7 Wikipedia language editions.
Protein · UniProt
Complement component C1q receptor
- Gene
- CD93
- Organism
- Homo sapiens (Human)
- Length
- 652 aa
- Molecular mass
- 68,560 Da
- Evidence
- 1: Evidence at protein level
Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2) (PubMed:7977768). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis (PubMed:24809468). Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent…
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
Show 2 more facts
- biological process
- signal transduction
- found in taxon
- Homo sapiens
Sources (4)
via Wikidata · CC0
~5 min read
Encyclopedic overview
7 sectionsContents
- Family
- Expression
- Function
- See also
- References
- Further reading
- External links
CD93 (Cluster of Differentiation 93) is a protein that in humans is encoded by the CD93 gene. CD93 is a C-type lectin transmembrane receptor which plays a role not only in cell–cell adhesion processes but also in host defense.
== Family == CD93 belongs to the Group XIV C-Type lectin family, a group containing three other members, endosialin (CD248), CLEC14A and thrombomodulin, a well characterized anticoagulant. All of them contain a C-type lectin domain, a series of epidermal growth factor like domains, a highly glycosylated mucin-like domain, a unique transmembrane domain and a short cytoplasmic tail. Due to their strong homology and their close proximity on chromosome 20, CD93 has been suggested to have arisen from the thrombomodulin gene through a duplication event.
Excerpted from Wikipedia’s “CD93 molecule” article, available under the CC BY-SA 4.0 licence.