CD93 molecule
Sign in to saveAlso known as C1qR, C1q receptor 1, C1qRp, C1q/MBL/SPA receptor, complement component C1q receptor, complement component 1 q subcomponent receptor 1, matrix-remodelling associated 4, matrix-remodeling-associated protein 4
CD93 (Cluster of Differentiation 93) is a protein that in humans is encoded by the CD93 gene. CD93 is a C-type lectin transmembrane receptor which plays a role not only in cell–cell adhesion processes but also in host defense.
Protein · UniProt
Complement component C1q receptor
- Gene
- CD93
- Organism
- Homo sapiens (Human)
- Length
- 652 aa
- Molecular mass
- 68,560 Da
- Evidence
- 1: Evidence at protein level
Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2) (PubMed:7977768). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis (PubMed:24809468). Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent…
Swiss-Prot (reviewed) · via UniProt
~5 min read
Article
7 sectionsContents
- Family
- Expression
- Function
- See also
- References
- Further reading
- External links
CD93 (Cluster of Differentiation 93) is a protein that in humans is encoded by the CD93 gene. CD93 is a C-type lectin transmembrane receptor which plays a role not only in cell–cell adhesion processes but also in host defense.
== Family == CD93 belongs to the Group XIV C-Type lectin family, a group containing three other members, endosialin (CD248), CLEC14A and thrombomodulin, a well characterized anticoagulant. All of them contain a C-type lectin domain, a series of epidermal growth factor like domains, a highly glycosylated mucin-like domain, a unique transmembrane domain and a short cytoplasmic tail. Due to their strong homology and their close proximity on chromosome 20, CD93 has been suggested to have arisen from the thrombomodulin gene through a duplication event.