CD83 molecule

Also known as hCD83, B-cell activation protein, CD83, CD83 antigen (activated B lymphocytes, immunoglobulin superfamily), cell surface protein HB15, CD83 antigen, cell-surface glycoprotein

thumb|Dimeric CD83 extracellular domain structure CD83 (Cluster of Differentiation 83) is a human protein encoded by the gene.

Protein · UniProt

CD83 antigen

Gene: CD83
Organism: Homo sapiens (Human)
Length: 205 aa
Molecular mass: 23,042 Da
Evidence: 1: Evidence at protein level

Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation (PubMed:21220452). In addition, acts as an important modulator of protective responses against acute infections (…

3D-structureDirect protein sequencingDisulfide bondGlycoproteinImmunoglobulin domainMembraneProteomics identificationReference proteome

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Swiss-Prot (reviewed) · via UniProt

Research

1,111 papers

The CD83 Molecule - An Important Immune Checkpoint.Frontiers in immunology · 2020
CD83: a regulatory molecule of the immune system with great potential for therapeutic application.Journal of medical and dental sciences · 2006
Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation.International journal of molecular sciences · 2022
CD83 expressed by macrophages is an important immune checkpoint molecule for the resolution of inflammation.Frontiers in immunology · 2023
CD83 suppresses endogenous March-I-dependent MHC class II ubiquitination, endocytosis, and degradation.Proceedings of the National Academy of Sciences of the United States of America · 2025

via PubMed

~6 min read

Article

13 sections

Contents

Structure
Gene
Function
Ligands
Positive selection
Regulatory T cells
Dendritic cells
B cells
Hair Growth
See also
References
Further reading
External links

thumb|Dimeric CD83 extracellular domain structure CD83 (Cluster of Differentiation 83) is a human protein encoded by the gene.

== Structure == The membrane-bound form of CD83 consists of an extracellular V-type immunoglobulin-like domain, a transmembrane domain and a cytoplasmic signaling tail. A free soluble form consists of the immunoglobulin-like domain alone. Membrane-bound CD83 is expected to form trimers. Soluble CD83 is able to assemble into dodecameric complexes.