CD3D
Sign in to saveAlso known as CD3-DELTA, IMD19, T3D, CD3d molecule, CD3 delta subunit of T-cell receptor complex, CD3DELTA
T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.
In the Vinony graph
Within Vinony's link graph, CD3D is referenced by 386 other articles, and connects out to PubMed, Ensembl genome database project and CD1.
It sits within the topics Clusters of differentiation and Genes on human chromosome 11.
Its subject is documented across 6 Wikipedia language editions.
Gene data
CD3D- Name
- CD3 delta subunit of T-cell receptor complex
- Type
- protein-coding
- Position
- 118,334,537–118,342,713 (−)
- Aliases
- CD3-DELTA, CD3DELTA, IMD19, T3D
- Ensembl
- ENSG00000167286
- RefSeq RNA
- NM_000732.6, NM_001040651.2, XM_054370480.1
- RefSeq protein
- NP_000723.1, NP_001035741.1, XP_054226455.1
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
CD3 delta subunit of T-cell receptor complex
- Symbol
- CD3D
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:118,334,537-118,342,713
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CD3D PDB 1xiw.png
Show 8 more facts
- HomoloGene ID
- 585
- expressed in
- bone marrow
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/915
- genomic start
- 118339075
- chromosome
- human chromosome 11
- genomic end
- 118342705
- cytogenetic location
- 11q23.3
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Interactions
- See also
- References
- Further reading
- External links
T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.
==Interactions== CD3D has been shown to interact with CD8A.
Excerpted from Wikipedia’s “CD3D” article, available under the CC BY-SA 4.0 licence.