Also known as CD3-DELTA, IMD19, T3D, CD3d molecule, CD3 delta subunit of T-cell receptor complex, CD3DELTA
T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009].
Biological process
T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.
==Interactions== CD3D has been shown to interact with CD8A.
via MyGene.info
via Wikidata · CC0
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).