CD3D

Name

CD3 delta subunit of T-cell receptor complex

Type

protein-coding

Position

118,334,537–118,342,705 (−)

Aliases

CD3-DELTA, CD3DELTA, IMD19, T3D

Ensembl

ENSG00000167286

RefSeq RNA

NM_000732.6, NM_001040651.2, XM_054370480.1

RefSeq protein

NP_000723.1, NP_001035741.1, XP_054226455.1

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009].

via MyGene.info

Gene · Ensembl

CD3 delta subunit of T-cell receptor complex

Symbol

CD3D

Biotype

Protein coding

Organism

Homo sapiens

Location

11:118,334,537-118,342,713

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein CD3D PDB 1xiw.png

via Wikidata · CC0