CD58 molecule
Sign in to saveAlso known as surface glycoprotein LFA-3, CD58, CD58 antigen, (lymphocyte function-associated antigen 3), lymphocyte function-associated antigen 3
thumb|right | alt=Visualization of the CD58 crystallized protein from the PDB identifier 1CCZ | Visualization of the CD58 crystallized protein from the PDB identifier 1CCZ CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APCs), particularly macrophages, and other tissue cells.
Protein · UniProt
Lymphocyte function-associated antigen 3
- Gene
- CD58
- Organism
- Homo sapiens (Human)
- Length
- 250 aa
- Molecular mass
- 28,147 Da
- Evidence
- 1: Evidence at protein level
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells
Swiss-Prot (reviewed) · via UniProt
Research
838 papers- CD58 Immunobiology at a Glance.Frontiers in immunology · 2021
- [Research Progress on Relationship between CD58 Molecule and ALL and Lymphoma -Review].Zhongguo shi yan xue ye xue za zhi · 2017
- Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies.Cell stem cell · 2024
- Investigation on correlation between expression of CD58 molecule and severity of hepatitis B.World journal of gastroenterology · 2006
- High Expression of CD58 and ALDH1A3 Predicts a Poor Prognosis in Basal-like Breast Cancer.Anticancer research · 2022
via PubMed
~8 min read
Article
7 sectionsContents
- Introduction
- CD58 and CD2 interaction
- Structure and localization of CD58
- Multiple sclerosis
- Rheumatoid arthritis
- References
- External links
thumb|right | alt=Visualization of the CD58 crystallized protein from the PDB identifier 1CCZ | Visualization of the CD58 crystallized protein from the PDB identifier 1CCZ CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APCs), particularly macrophages, and other tissue cells.
CD58 binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion and recognition between the T cells and Professional Antigen Presenting Cells, facilitating signal transduction necessary for an immune response. This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation, when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to.