CD58 molecule
Sign in to saveAlso known as surface glycoprotein LFA-3, CD58, CD58 antigen, (lymphocyte function-associated antigen 3), lymphocyte function-associated antigen 3
thumb|right | alt=Visualization of the CD58 crystallized protein from the PDB identifier 1CCZ | Visualization of the CD58 crystallized protein from the PDB identifier 1CCZ CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APCs), particularly macrophages, and other tissue cells.
In the Vinony graph
Within Vinony's link graph, CD58 molecule is referenced by 369 other articles, and connects out to T-lymphocytes, CD1 and brain.
It sits within the topics Genes on human chromosome 1, Human proteins and Protein pages needing a picture.
Its subject is documented across 8 Wikipedia language editions.
Protein · UniProt
Lymphocyte function-associated antigen 3
- Gene
- CD58
- Organism
- Homo sapiens (Human)
- Length
- 250 aa
- Molecular mass
- 28,147 Da
- Evidence
- 1: Evidence at protein level
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells
Swiss-Prot (reviewed) · via UniProt
Research
838 papers- CD58 Immunobiology at a Glance.Frontiers in immunology · 2021
- [Research Progress on Relationship between CD58 Molecule and ALL and Lymphoma -Review].Zhongguo shi yan xue ye xue za zhi · 2017
- Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies.Cell stem cell · 2024
- Investigation on correlation between expression of CD58 molecule and severity of hepatitis B.World journal of gastroenterology · 2006
- High Expression of CD58 and ALDH1A3 Predicts a Poor Prognosis in Basal-like Breast Cancer.Anticancer research · 2022
via PubMed
Wikidata facts
- Instance of
- protein
Show 2 more facts
- cell component
- extracellular exosome
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
~8 min read
Encyclopedic overview
7 sectionsContents
- Introduction
- CD58 and CD2 interaction
- Structure and localization of CD58
- Multiple sclerosis
- Rheumatoid arthritis
- References
- External links
thumb|right | alt=Visualization of the CD58 crystallized protein from the PDB identifier 1CCZ | Visualization of the CD58 crystallized protein from the PDB identifier 1CCZ CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APCs), particularly macrophages, and other tissue cells.
CD58 binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion and recognition between the T cells and Professional Antigen Presenting Cells, facilitating signal transduction necessary for an immune response. This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation, when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to.
Excerpted from Wikipedia’s “CD58 molecule” article, available under the CC BY-SA 4.0 licence.