CD2 molecule
Sign in to saveAlso known as CD2 antigen (p50), sheep red blood cell receptor, T-cell surface antigen CD2, LFA-2, T-cell surface antigen T11/Leu-5, erythrocyte receptor, LFA-3 receptor, CD2, rosette receptor
CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor.
Protein · UniProt
T-cell surface antigen CD2
- Gene
- CD2
- Organism
- Homo sapiens (Human)
- Length
- 351 aa
- Molecular mass
- 39,448 Da
- Evidence
- 1: Evidence at protein level
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function
Swiss-Prot (reviewed) · via UniProt
Research
4,966 papers- CD2 expressing innate lymphoid and T cells are critical effectors of immunopathogenesis in hidradenitis suppurativa.Proceedings of the National Academy of Sciences of the United States of America · 2024
- CD2.Journal of biological regulators and homeostatic agents · 2000
- Topology of the CD2-CD48 cell-adhesion molecule complex: implications for antigen recognition by T cells.Current biology : CB · 1995
- CD59 molecule: a second ligand for CD2 in T cell adhesion.European journal of immunology · 1992
- Functional study of tilapia T cell activation stimulus signal molecule CD2.Fish & shellfish immunology · 2025
via PubMed
~1 min read
Article
7 sectionsContents
- Function
- Diagnostic relevance
- Classification
- Interactions
- References
- Further reading
- External links
CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor.
== Function == It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells.