CD96
Sign in to saveAlso known as TACTILE, CD96 molecule
CD96 (Cluster of Differentiation 96) or Tactile (T cell activation, increased late expression) is a protein that in humans is encoded by the CD96 gene. CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as DNAM-1). The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splic
In the Vinony graph
Vinony's link graph records 364 inbound references to CD96, and connects out to PubMed, Ensembl genome database project and protein.
It sits within the topics Clusters of differentiation and Genes on human chromosome 3.
Vinony links it to 5 Wikipedia language editions.
Gene data
CD96- Name
- CD96 molecule
- Type
- protein-coding
- Position
- 111,292,719–111,680,594 (+)
- Aliases
- TACTILE
- Ensembl
- ENSG00000153283
- RefSeq RNA
- NM_001318889.2, NM_001410800.1, NM_005816.5, NM_198196.3, NR_134917.2
- RefSeq protein
- NP_001305818.1, NP_001397729.1, NP_005807.1, NP_937839.1, XP_006713532.1
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
CD96 molecule
- Symbol
- CD96
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:111,292,719-111,680,594
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 68489
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10225
- genomic end
- 111384597
- genomic start
- 111011566
- chromosome
- human chromosome 3
- cytogenetic location
- 3q13.13-q13.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
CD96 (Cluster of Differentiation 96) or Tactile (T cell activation, increased late expression) is a protein that in humans is encoded by the CD96 gene. CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as DNAM-1). The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.
== Function ==
Excerpted from Wikipedia’s “CD96” article, available under the CC BY-SA 4.0 licence.