CD80 molecule
Sign in to saveAlso known as B7, BB1, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD80, T-lymphocyte activation antigen CD80, costimulatory factor CD80, B-lymphocyte activation antigen B7, CTLA-4 counter-receptor B7.1
The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with costimulatory receptors CD28, CTLA-4 (CD152) and the p75 neurotrophin receptor.
Protein · UniProt
T-lymphocyte activation antigen CD80
- Gene
- CD80
- Organism
- Homo sapiens (Human)
- Length
- 288 aa
- Molecular mass
- 33,048 Da
- Evidence
- 1: Evidence at protein level
Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:38467718). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:12196291). In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines (PubMed:10438913). Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor,…
Swiss-Prot (reviewed) · via UniProt
Research
6,170 papers- PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity.Nature immunology · 2022
- Molecular and Functional Analyses of the Primordial Costimulatory Molecule CD80/86 and Its Receptors CD28 and CD152 (CTLA-4) in a Teleost Fish.Frontiers in immunology · 2022
- Research progress of CD80 in the development of immunotherapy drugs.Frontiers in immunology · 2024
- Discovery of selective small-molecule CD80 inhibitors.Journal of biomolecular screening · 2007
- Urinary CD80: a biomarker for a favorable response to corticosteroids in minimal change disease.Pediatric nephrology (Berlin, Germany) · 2018
via PubMed
Clinical Trials
1 registered- PHASE1WITHDRAWNCancer/Testis Antigen Immunotherapy Phase I Study With 740-CTA Vaccinia VirusUniversity Hospital, Basel, Switzerland · NCT03110445
Wikidata facts
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Article
6 sectionsContents
- Structure
- Function
- Clinical significance
- See also
- References
- External links
The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with costimulatory receptors CD28, CTLA-4 (CD152) and the p75 neurotrophin receptor.
== Structure == CD80 is a member of the B7 family, which consists of molecules present at APCs and their receptors present on the T-cells. CD80 is present specifically on DC, activated B-cells, and macrophages, but also T-cells. CD80 is also a transmembrane glycoprotein and a member of the Ig superfamily. It is composed of 288 amino acids, and its mass is 33 kDa. It consists of two Ig-like extracellular domains (208 AA), a transmembrane helical segment (21 AA), and a short cytoplasmic tail (25 AA). The Ig-like extracellular domains are formed by single V-type and C2-type domains. It is expressed as both monomers or dimers, but predominantly dimers. These two forms exist in dynamic equilibrium.