CD28 molecule
Sign in to saveAlso known as CD28, T-cell-specific surface glycoprotein CD28, CD28 antigen, TP44, CD28 Antigens
CD28 (cluster of differentiation 28) is a protein expressed on T cells that provides essential co-stimulatory signals required for T cell activation and survival. When T cells are stimulated through CD28 in conjunction with the T-cell receptor (TCR), it enhances the production of various interleukins, particularly IL-6. CD28 serves as a receptor for CD80 (B7.1) and CD86 (B7.2), proteins found on antigen-presenting cells (APCs).
Protein · UniProt
T-cell-specific surface glycoprotein CD28
- Gene
- CD28
- Organism
- Homo sapiens (Human)
- Length
- 220 aa
- Molecular mass
- 25,066 Da
- Evidence
- 1: Evidence at protein level
Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, PubMed:7568038). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells (PubMed:24665965). Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets (PubMed:12196291, PubMed:1650475, PubMed:35397202). Mechanist…
Swiss-Prot (reviewed) · via UniProt
~7 min read
Article
9 sectionsContents
- Signaling
- Structure
- CD28 family members
- As a drug target
- Interactions
- See also
- References
- Further reading
- External links
CD28 (cluster of differentiation 28) is a protein expressed on T cells that provides essential co-stimulatory signals required for T cell activation and survival. When T cells are stimulated through CD28 in conjunction with the T-cell receptor (TCR), it enhances the production of various interleukins, particularly IL-6. CD28 serves as a receptor for CD80 (B7.1) and CD86 (B7.2), proteins found on antigen-presenting cells (APCs).
CD28 is the only B7 receptor consistently expressed on naive T cells. In the absence of CD28:B7 interaction, a naive T cell's TCR engagement with an MHC:antigen complex leads to anergy. CD28 is also expressed on stromal cells of the bone marrow, plasma cells, neutrophils, and eosinophils, although its function in these cells is not fully understood.