CD209
Sign in to saveAlso known as CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209 molecule, hDC-SIGN
DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene.
In the Vinony graph
Within Vinony's link graph, CD209 is referenced by 377 other articles, and connects out to PubMed, dendritic cell and Ensembl genome database project.
It is catalogued under topics including Clusters of differentiation, C-type lectins and Genes on human chromosome 19.
Its subject is documented across 8 Wikipedia language editions.
Gene data
CD209- Name
- CD209 molecule
- Type
- protein-coding
- Position
- 7,739,993–7,747,623 (−)
- Aliases
- CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, hDC-SIGN
- Ensembl
- ENSG00000090659
- RefSeq RNA
- NM_001144893.2, NM_001144894.2, NM_001144895.2, NM_001144896.2, NM_001144897.2
- RefSeq protein
- NP_001138365.1, NP_001138366.1, NP_001138367.1, NP_001138368.1, NP_001138369.1
This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
CD209 molecule
- Symbol
- CD209
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:7,739,993-7,747,623
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CD209 PDB 1k9i.png
Show 8 more facts
- HomoloGene ID
- 128353
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/30835
- genomic end
- 7812464
- genomic start
- 7739993
- chromosome
- human chromosome 19
- cytogenetic location
- 19p13.2
- expressed in
- duodenum
via Wikidata · CC0
~6 min read
Encyclopedic overview
9 sectionsContents
- Function
- Clinical significance
- HIV infection
- Ebola infection
- SARS-CoV-2
- Gene family
- References
- Further reading
- External links
DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene.
DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds with high affinity to high-mannose type N-glycans, a class of PAMPs (pathogen associated molecular patterns) commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis. On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and activation of CD4+ T cells, as well as recognition of pathogen haptens.
Excerpted from Wikipedia’s “CD209” article, available under the CC BY-SA 4.0 licence.