TLX3
Sign in to saveAlso known as HOX11L2, RNX, T-cell leukemia homeobox 3, T cell leukemia homeobox 3
T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.
Gene data
TLX3- Name
- T cell leukemia homeobox 3
- Type
- protein-coding
- Position
- 171,309,191–171,312,139 (+)
- Aliases
- HOX11L2, RNX
- Ensembl
- ENSG00000164438
- RefSeq RNA
- NM_021025.4
- RefSeq protein
- NP_066305.2
The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
T cell leukemia homeobox 3
- Symbol
- TLX3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:171,309,191-171,312,139
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 23181
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/30012
- genomic end
- 171312139
- genomic start
- 171309248
- chromosome
- human chromosome 5
- cytogenetic location
- 5q35.1
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.
RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993).[supplied by OMIM]
Excerpted from Wikipedia’s “TLX3” article, available under the CC BY-SA 4.0 licence.