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GeneQ18030577· pop 6· linked from 13 articles

PLAG1

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Also known as PSA, SGPA, ZNF912, PLAG1 zinc finger, SRS4

Zinc finger protein PLAG1 is a protein that in humans is encoded by the PLAG1 gene.

Gene data

PLAG1

Name: PLAG1 zinc finger
Type: protein-coding
Position: 56,160,909–56,211,333 (−)
Aliases: PSA, SGPA, SRS4, ZNF912
Ensembl: ENSG00000181690
RefSeq RNA: NM_001114634.2, NM_001114635.2, NM_002655.3, XM_017013576.2, XM_047421866.1
RefSeq protein: NP_001108106.1, NP_001108107.1, NP_002646.2, XP_016869065.1, XP_047277822.1

Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of DNA-templated transcription positive regulation of gene expression negative regulation of gene expression positive regulation of transcription by RNA polymerase II positive regulation of glial cell proliferation

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity

Cellular component

nucleus nucleus nucleoplasm cytoplasm nuclear body nuclear speck

via MyGene.info

Gene · Ensembl

PLAG1 zinc finger

Symbol: PLAG1
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:56,160,909-56,211,357
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 1993
exact match: identifiers.org/ncbigene/5324
genomic end: 57123883
genomic start: 56160909
cytogenetic location: 8q12.1

Sources (4)

via Wikidata · CC0

~1 min read

Article

5 sections

Contents

Function
Interactions
References
Further reading
External links

Zinc finger protein PLAG1 is a protein that in humans is encoded by the PLAG1 gene.

== Function ==

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Categories

Genes on human chromosome 8 Transcription factors