CD34 molecule
Sign in to saveAlso known as Antigens, CD34, CD34 antigen, CD34, hematopoietic progenitor cell antigen CD34
CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species.
Protein · UniProt
Hematopoietic progenitor cell antigen CD34
- Gene
- CD34
- Organism
- Homo sapiens (Human)
- Length
- 385 aa
- Molecular mass
- 40,716 Da
- Evidence
- 1: Evidence at protein level
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins
Swiss-Prot (reviewed) · via UniProt
Research
21,410 papers- CD34 molecule epitope distribution on cells of haematopoietic origin.Leukemia & lymphoma · 1998
- The CD34 molecule and hematopoietic progenitor cell studies--a challenge in clinical medicine.Vox sanguinis · 1998
- Homing-associated cell adhesion molecule (H-CAM/CD44) on human CD34+ hematopoietic progenitor cells.Leukemia & lymphoma · 2000
- Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2006
- Molecular features of CD34: a hemopoietic progenitor cell-associated molecule.Leukemia · 1992
via PubMed
~5 min read
Article
8 sectionsContents
- Function
- Tissue distribution
- Clinical applications
- Interactions
- See also
- References
- Further reading
- External links
CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species.
CD34 derives its name from the cluster of differentiation protocol that identifies cell surface antigens. CD34 was first described as a cell surface glycoprotein on hematopoietic stem cells and functions as a cell-cell adhesion factor. It may also mediate the attachment of hematopoietic stem cells to bone marrow extracellular matrix or directly to stromal cells. Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Due to these historical and clinical associations, CD34 expression is almost ubiquitously related to hematopoietic cells; however, it is actually found on many other cell types as well.