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GeneQ18027994· pop 8· linked from 843 articles

IRF2

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Also known as IRF-2, interferon regulatory factor 2

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.

Gene data

IRF2

Name: interferon regulatory factor 2
Type: protein-coding
Position: 184,385,702–184,474,558 (−)
Aliases: IRF-2
Ensembl: ENSG00000168310
RefSeq RNA: NM_002199.4
RefSeq protein: NP_002190.2

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II immune system process regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II

Molecular function

transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific

Cellular component

chromatin chromatin nucleus nucleus nucleoplasm nucleoplasm chromosome cytosol

Pathways

Hemostasis Cytokine Signaling in Immune system Immune System Regulated Necrosis Programmed Cell Death Pyroptosis Interferon gamma signaling Interferon alpha/beta signaling Interferon Signaling Factors involved in megakaryocyte development and platelet production

via MyGene.info

Gene · Ensembl

interferon regulatory factor 2

Symbol: IRF2
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:184,385,651-184,474,558
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein IRF2 PDB 1irf.png

Show 6 more facts

HomoloGene ID: 1659
exact match: identifiers.org/ncbigene/3660
genomic end: 184474558
genomic start: 184385702
cytogenetic location: 4q35.1
Commons category: Interferon regulatory factor-2, IRF-2

Sources (3)

via Wikidata · CC0

~1 min read

Article

6 sections

Contents

Function
See also
Interactions
References
Further reading
External links

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.

== Function ==

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Categories

Genes on human chromosome 4 Transcription factors