CASP1

Name

caspase 1

Type

protein-coding

Position

105,023,581–105,035,250 (−)

Aliases

ICE, IL1BC, P45

Ensembl

ENSG00000137752

RefSeq RNA

NM_001223.5, NM_001257118.3, NM_001257119.3, NM_033292.4, NM_033293.4

RefSeq protein

NP_001214.1, NP_001244047.1, NP_001244048.1, NP_150634.1, NP_150635.1

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012].

via MyGene.info

Gene · Ensembl

caspase 1

Symbol

CASP1

Biotype

Protein coding

Organism

Homo sapiens

Location

11:105,023,581-105,035,250

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein CASP1 PDB 1bmq.png

via Wikidata · CC0