NLRP7
Sign in to saveAlso known as CLR19.4, HYDM, NALP7, NOD12, PAN7, PYPAF3, NLR family, pyrin domain containing 7, NLR family pyrin domain containing 7
NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene.
Gene data
NLRP7- Name
- NLR family pyrin domain containing 7
- Type
- protein-coding
- Position
- 54,923,454–54,966,312 (−)
- Aliases
- CLR19.4, HYDM, NALP7, NOD12, OZEMA25, PAN7, PYPAF3
- Ensembl
- ENSG00000277071
- RefSeq RNA
- NM_001127255.2, NM_001405531.1, NM_139176.4, NM_206828.4, XM_047438386.1
- RefSeq protein
- NP_001120727.1, NP_001392460.1, NP_631915.2, NP_996611.2, XP_047294342.1
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
NLR family pyrin domain containing 7
- Symbol
- NLRP7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR19LRC_LRC_J_CTG3_1:931,032-955,028
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene.
== Function ==
Excerpted from Wikipedia’s “NLRP7” article, available under the CC BY-SA 4.0 licence.